Pathophysiology of meningococcal meningitis and septicaemia.

Risk factors for death from meningococcal infection in Recife, Brazil.

To determine the case fatality rate and risk factors for death in children with invasive meningococcal infection, 163 children admitted with meningococcal disease to the Instituto Materno Infantil de Pernambuco, a tertiary paediatric teaching hospital in Recife, Brazil, were included in this retrospective cohort study. Cases were categorised as meningitis, septicaemia and septicaemia with menin...

The early management of meningococcal disease

Neisseria meningitidis is an important cause of bacterial meningitis, particularly in infants over three months old and in teenagers. The relative importance of meningococcal disease over invasive Haemophilus influenzae disease has increased following the introduction ofHib capsular vaccines in 1990. In about one fifth of infections with Neisseria meningitidis the organism causes a predominantl...

Prospects for eradication of meningococcal disease

Meningococcal meningitis and septicaemia remain a serious global health threat. This review focuses on the epidemiology of meningococcal disease following the recent implementation of effective vaccines and the potential utility of a vaccine against serogroup B meningococcus.

Investigating the aetiology of and evaluating the impact of the Men C vaccination programme on probable meningococcal disease in England and Wales.

The aims were to (1) investigate the aetiology of probable meningococcal disease, where a clinical diagnosis is made in the absence of laboratory data, and (2) evaluate the impact of the Men C vaccination programme in England and Wales. Multiple linear regression analyses were carried out using data reported to Enhanced Surveillance of Meningococcal Disease (ESMD) and laboratory reports of isol...

Early management of suspected bacterial meningitis and meningococcal septicaemia in adults.